What is the significance of genetic variants to those that carry them?
How do we determine the significance of genetic variants?
We want to be able to accurately predict the phenotype of any and all genetic variants. Our approach is to collect as much phenotype information--at high and low resolution--as is feasible for the largest number of variants and then leverage high-throughput experimental and computational methods to fill in the details for yet uncharacterized variants. To develop this methodology, we are starting with ion channels involved in the heart contraction cycle. See this talk on YouTube for an overview to our research program.